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WFU Physics Seminars

WFU Physics Colloquium

TITLE: "The Physics of Protein and RNA folding"

SPEAKER: Dr. Lisa Lapidus,

Department of Physics
Stanford University

TIME: Thursday Jan. 22, 2004 at 4 PM

PLACE: George P. Williams, Jr. Lecture Hall, (Olin 101)

Refreshments will be served at 3:30 PM in the lounge. All interested persons are cordially invited to attend.

ABSTRACT

In this talk I shall present some aspects of macromolecular folding, the process by which polypeptide and RNA chains assume biologically active conformations. Folding is spontaneous and depends in detail on the physical interactions within the chain and with the surrounding water. In particular I shall focus on the early stages of folding in which the chain is relatively unstructured and may be described by models from polymer physics. The exact nature of the unfolded state may determine the subsequent folding steps and play a crucial role in aggregation, misfolding and subsequent disease.

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