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Wake Forest Physics… |
WFU Physics Colloquium
TITLE:
Investigating the Mechanisms of Amyloid Peptides's Aggregation
SPEAKER:
Dr. Yan Lu ,
TIME: Wednesday November 7, 2012
PLACE: Room 101 Olin Physical Laboratory
Refreshments will be served at 3:30 PM in the Olin Lounge. All interested persons are cordially invited to attend.
ABSTRACT
Protein or peptide may misfold and aggregate under some conditions
into amyloid fibrils, which is associated with many human disease,
such as Alzheimer's disease, Parkinson's disease. The amyloid fibrils
share common structural characteristics, eg. cross beta x-ray
diffraction pattern. In this talk, I will show that: 1, different
peptides may have different aggregation characteristics, including
structural, dynamical and thermodynamical properties. 2, single-point
mutant may also alter the aggregation characteristics.
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