Wake Forest Physics
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WFU Physics Colloquium
TITLE:
Molecular Dynamic Simulation of Bio-Molecular Dynamics, Folding, and Assembly
SPEAKER:
Rongzhong Li
TIME: Tuesday April 28, 2015 at 1:00 PM
PLACE: Room 107 Olin Physical Laboratory
ABSTRACT
A major goal in molecular biophysics is to understand how
biomolecules fold into specific structures to carry out cellular
processes to result in a functioning organism. Computational
molecular dynamics (MD) simulations can characterize biomolecules
at a microscopic level. These indispensable tools use classical
mechanical approaches to describe biomolecular dynamics, folding,
and binding mechanisms. Although there are many different types of
MD simulations, I will focus on two classes of approaches: empirical
force field and coarse-grained native structure based ones.
In the present thesis, I will discuss recent MD simulation studies of
RNA, protein-RNA, and protein-nanoparticle interactions with direct
comparisons to experiments whenever possible to validate our
approaches.
Specifically, I will present three following three projects:
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